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Last year I was going for a month long trip to Thailand. The company I work at was opening a new development department there and I was to provide the support on site. My doctor informed me about the preventive measures I had to take before going to that region in order not to fall ill with malaria. He said Quinine was the best medication from his point of view. As I had no objections I ordered the drug and started taking it. No side effects and no obvious positive effect as well. But then I realized the importance of such medications when I saw people suffering from malaria. The disease is really horrible and I?m grateful to the producers of Quinine as the medication they created protected me from a life-threat. Would recommend it to others!
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Application of 200µM PQQ to isolated neurons undergoing epileptic activity can fully abolish such activity if induced by reducing agents (no effect on epileptic activity induced by other means), supporting the role PQQ plays in epilepsy via NMDA antagonism which may occurs to limited levels at concentrations as low as 5µM.
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